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Jenifer Saffi, PhD

 

 

Contact information

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+55 51 33038861

+55 51 33038872

 

Research information 

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Address

Basic Health Sciences Department - Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) - Rua Sarmento Leite, 245 - Porto Alegre - RS - Brazil - CEP 90050-170

 

Biography

Jenifer Saffi is an associate professor tenure of the Basic Health Sciences Department at the Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) (2009), where she teaches basic biochemistry and coordinates the Genetic Toxicology Lab. She holds an academic degree in Pharmacy from the Universidade Federal do Rio Grande do Sul (UFRGS) (1992),  a Ph.D (1999) in Biological Sciences (Biochemistry) from the Universidade Federal do Rio Grande do Sul and Post-Doc at the  “Institut de Cancérologie Gustave Roussy” in Villejuif – France (2007-2008). During her PhD she spent 9 months at Genzentrum, in Munich (Germany) under the supervision of Ernst-Ludwick Winnacker and 3 months at the MIT (Boston/USA) under the supervision of Leonard Guarente. She is a CNPq Productivity Researcher (1C), consultant of several Brazilian funding agencies such as CAPES, CNPq and FAPERGS.  She has been a member of the National Committee of Biosafety (CTNBio – Brazil) since 2014. She has more than 100 published papers.

 

Reasearch Interest

She holds experience in Genetic Toxicology. Her main research area is DNA repair and mutagenesis in eukaryotic cells, focusing on the involvement of the DNA repair mechanisms in the cytotoxicity of antitumor drugs and DNA damage response in cancer.

 

Most Relevant Publications

  1. Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy
  2. Imbalance in DNA repair machinery is associated with BRAFV600E mutation and tumor aggressiveness in papillary thyroid carcinoma
  3. Pathways of cardiac toxicity: comparison between chemotherapeutic drugs doxorubicin and mitoxantrone
  4. Role of nucleotide excision repair proteins in response to DNA damage induced by topoisomerase II inhibitors
  5. Influence of nucleotide excision repair on mitoxantrone cytotoxicity
  6. DNA alkylation damage and autophagy induction
  7. PARPs and the DNA damage response
  8. Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions
  9. Effect of the anti-neoplastic drug doxorubicin on XPD-mutated DNA repair-deficient human cells
  10. DNA damage induced by the anthracycline cosmomycin D in DNA repair-deficient cells

 

 


 


Universidade Federal de Ciências da Saúde de Porto Alegre
Rua Sarmento Leite, 245 - Porto Alegre, Rio Grande do Sul, Brasil - CEP 90050-170
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